Cellular Immune Activation in Cerebrospinal Fluid From Ugandans With Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome | Zendy

David B. Meya | Zendy; Samuel Okurut | Zendy; Godfrey Zziwa | Zendy; Melissa A. Rolfes | Zendy; M.C. Kelsey | Zendy; Stephen Cose | Zendy; Moses Joloba | Zendy; Prossy Naluyima | Zendy; Brent E. Palmer | Zendy; Andrew Kambugu | Zendy; Harriet MayanjaKizza | Zendy; Paul R. Bohjanen | Zendy; Michael A. Eller | Zendy; Sharon M. Wahl | Zendy; David R. Boulware | Zendy; Yukari C. Manabe | Zendy; Edward N. Janoff | Zendy

Open Access

Cellular Immune Activation in Cerebrospinal Fluid From Ugandans With Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome

Author(s) -

David B. Meya,

Samuel Okurut,

Godfrey Zziwa,

Melissa A. Rolfes,

M.C. Kelsey,

Stephen Cose,

Moses Joloba,

Prossy Naluyima,

Brent E. Palmer,

Andrew Kambugu,

Harriet MayanjaKizza,

Paul R. Bohjanen,

Michael A. Eller,

Sharon M. Wahl,

David R. Boulware,

Yukari C. Manabe,

Edward N. Janoff

Publication year - 2014

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiu664

Subject(s) - immune reconstitution inflammatory syndrome , cerebrospinal fluid , immunology , cd8 , immune system , proinflammatory cytokine , pathogenesis , inflammation , peripheral blood mononuclear cell , monocyte , meningitis , biology , medicine , virus , pathology , antiretroviral therapy , viral load , in vitro , psychiatry , biochemistry

Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid (CSF). The immunopathogenesis of CM immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy at the site of infection is poorly understood.

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