Open AccessDifferences in New Variant of Concern Replication at Physiological Temperatures In Vitro
Author(s) -
Charles B. Stauft,
Kotou Sangare,
Tony T. Wang
Publication year - 2022
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiac264
Subject(s) - replication (statistics) , infectivity , biology , in vitro , virus , virology , viral replication , genetics
Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34°C compared to 37°C while Omicron replication is balanced between temperatures.
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