Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P | Zendy

TsunYung Kuo | Zendy; Chia-En Lien | Zendy; YiJiun Lin | Zendy; MeeiYun Lin | Zendy; Chung-Chin Wu | Zendy; Wei-Hsuan Tang | Zendy; John D. Campbell | Zendy; Paula Traquina | Zendy; Ya-Shan Chuang | Zendy; Luke Tzu-Chi Liu | Zendy; Jinyi Cheng | Zendy; Charles Chen | Zendy

Open Access

Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P

Author(s) -

TsunYung Kuo,

Chia-En Lien,

YiJiun Lin,

MeeiYun Lin,

Chung-Chin Wu,

Wei-Hsuan Tang,

John D. Campbell,

Paula Traquina,

Ya-Shan Chuang,

Luke Tzu-Chi Liu,

Jinyi Cheng,

Charles Chen

Publication year - 2022

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiac153

Subject(s) - virology , titer , recombinant dna , neutralizing antibody , hamster , covid-19 , neutralization , virus , vero cell , vaccination , antibody , biology , beta (programming language) , mesocricetus , medicine , immunology , microbiology and biotechnology , gene , pathology , genetics , disease , computer science , programming language , infectious disease (medical specialty)

SARS-CoV-2 Variants of Concern (VoCs) negatively impact the effectiveness of vaccines. In this study, we challenge hamsters with the Delta variant after two- or three-dose inoculations with SARS-CoV-2 vaccines constructed from stabilized prefusion spike proteins (S-2P) of Wuhan (W) and Beta (B) variants. Compared to three doses of W S-2P, two doses of W S-2P followed by a third dose of B S-2P induced the highest neutralizing antibody titer against live SARS-CoV-2 virus and enhanced neutralization of Omicron variant pseudovirus. Reduced lung live virus titer and pathology suggested that all vaccination regimens protect hamsters from SARS-CoV-2 Delta variant challenge.

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