Open AccessSARS-CoV-2 Placentitis Associated With B.1.617.2 (Delta) Variant and Fetal Distress or Demise
Author(s) -
Lydia L. Shook,
Sara Brigida,
James Regan,
James P. Flynn,
Abbas Mohammadi,
Behzad Etemad,
Molly Siegel,
Mark A. Clapp,
Jonathan Z. Li,
Drucilla J. Roberts,
Andrea G. Edlow
Publication year - 2022
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiac008
Subject(s) - pregnancy , medicine , fetus , fetal distress , viremia , covid-19 , demise , disease , immunology , human immunodeficiency virus (hiv) , biology , infectious disease (medical specialty) , genetics , political science , law
There is limited information on the specific impact of maternal infection with the SARS-CoV-2 B.1.617.2 (delta) variant on pregnancy outcomes. We present 2 cases of intrauterine fetal demise and 1 case of severe fetal distress in the setting of maternal infection with delta-variant SARS-CoV-2. In all cases, fetal demise or distress occurred within 14 days of COVID-19 diagnosis. Evaluation revealed maternal viremia, high nasopharyngeal viral load, evidence of placental infection with delta-variant SARS-CoV-2, and hallmark features of SARS-CoV-2 placentitis. We suggest that delta-variant SARS-CoV-2 infection during pregnancy warrants vigilance for placental dysfunction and fetal compromise regardless of disease severity.
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