Open AccessYearlong COVID-19 Infection Reveals Within-Host Evolution of SARS-CoV-2 in a Patient With B-Cell Depletion
Author(s) -
Véronique Nussenblatt,
Allison Roder,
Sanchita Basu Das,
Emmie de Wit,
Jung-Ho Youn,
Stephanie Banakis,
Alexandra Mushegian,
Christopher Mederos,
Wei Wang,
Matthew Chung,
Lizzette Pérez-Pérez,
Tara N. Palmore,
Jennifer N. Brudno,
James N. Kochenderfer,
Elodie Ghedin
Publication year - 2021
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab622
Subject(s) - viral shedding , virology , biology , covid-19 , virus , coronavirus , persistence (discontinuity) , viral infection , viral evolution , immunology , disease , medicine , gene , infectious disease (medical specialty) , genetics , rna , outbreak , geotechnical engineering , pathology , engineering
B-cell–depleting therapies may lead to prolonged disease and viral shedding in individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and this viral persistence raises concern for viral evolution. We report sequencing of early and late samples from a 335-day infection in an immunocompromised patient. The virus accumulated a unique deletion in the amino-terminal domain of the spike protein, and complete deletion of ORF7b and ORF8, the first report of its kind in an immunocompromised patient. Unique viral mutations found in this study highlight the importance of analyzing viral evolution in protracted SARS-CoV-2 infection, especially in immunosuppressed hosts.
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