Open AccessProper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection
Author(s) -
Laura PérezLago,
Helena Martínez-Lozano,
José Antonio Pajares Díaz,
Arantxa Díaz Gómez,
Marina Machado,
Pedro J. SolaCampoy,
Marta Herránz,
Sergio BuenestadoSerrano,
Maricela Valerio,
María Olmedo,
Cristina Andrés Zayas,
Iñaki Comas,
Fernando GónzálezCandelas,
Rafael Bañares,
Pilar Catalán,
Patricia Muñóz,
Darı́o Garcı́a de Viedma
Publication year - 2021
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab302
Subject(s) - covid-19 , medicine , transmission (telecommunications) , pediatrics , virology , outbreak , disease , infectious disease (medical specialty) , electrical engineering , engineering
A 77-year-old man (case R) with previous diagnosis of a mild COVID-19 episode was hospitalized 35 days later. On day 23 postadmission, he developed a second COVID-19 episode, now severe, and finally died. Initially, case R’s COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR–positive roommate. However, whole-genome sequencing indicated that case R’s recurrence corresponded to a reactivation of the strain involved in his first episode. Case R’s reactivation had major consequences, leading to a more severe episode, and causing subsequent transmission to another 2 hospitalized patients, 1 of them with fatal outcome.
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