Open AccessPeripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated With Increased Maternal Microchimerism in the Offspring
Author(s) -
Neta Simon,
Jaclyn Shallat,
J. C. Houck,
Prasanna Jagannathan,
Mary Prahl,
Mary Muhindo,
Abel Kakuru,
Peter Olwoch,
Margaret E. Feeney,
Whitney E. Harrington
Publication year - 2021
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab275
Subject(s) - parasitemia , malaria , microchimerism , plasmodium falciparum , pregnancy , offspring , immunology , odds ratio , medicine , biology , fetus , physiology , obstetrics , genetics
Placental malaria has been associated with increased cord blood maternal microchimerism (MMc), which in turn may affect susceptibility to malaria in the offspring. We sought to determine the impact of maternal peripheral Plasmodium falciparum parasitemia during pregnancy on MMc and to determine whether maternal cells expand during primary parasitemia in the offspring.