Open AccessPsychosocial Stress Alters the Immune Response and Results in Higher Viral Load During Acute Simian Immunodeficiency Virus Infection in a Pigtailed Macaque Model of Human Immunodeficiency Virus
Author(s) -
Selena M. Guerrero-Martin,
Leah H. Rubin,
Kirsten M. McGee,
Erin N. Shirk,
Suzanne E. Queen,
Ming Li,
Brandon Bullock,
Bess Carlson,
Robert J. Adams,
Lúcio Gama,
David R. Graham,
Christine Zink,
Janice E. Clements,
Joseph L. Mankowski,
Kelly A. Metcalf Pate
Publication year - 2021
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab252
Subject(s) - simian immunodeficiency virus , immunology , viral load , virology , psychosocial , viral disease , pandemic , virus , immunodeficiency , disease , immune system , medicine , biology , infectious disease (medical specialty) , psychiatry , covid-19
Although social distancing is a key public health response during viral pandemics, psychosocial stressors, such as social isolation, have been implicated in adverse health outcomes in general [1] and in the context of infectious disease, such as human immunodeficiency virus (HIV) [2, 3]. A comprehensive understanding of the direct pathophysiologic effects of psychosocial stress on viral pathogenesis is needed to provide strategic and comprehensive care to patients with viral infection.