Open AccessPlacental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus
Author(s) -
Lisa M. Bebell,
Kalynn Parks,
Mylinh H Le,
Joseph Ngonzi,
Julian Adong,
Adeline A. Boatin,
Ingrid V. Bassett,
Mark J. Siedner,
Alison D. Gernand,
Drucilla J. Roberts
Publication year - 2021
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab201
Subject(s) - decidua , vascular endothelial growth factor , preeclampsia , placental growth factor , serostatus , medicine , cd31 , placenta , immunostaining , viral load , pathology , pregnancy , immunohistochemistry , andrology , biology , immunology , fetus , virus , vegf receptors , genetics
Women with human immunodeficiency virus (HIV) (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to antiretroviral therapy and medical comorbid conditions. However, these features and their underlying pathophysiologic mechanisms have not been well characterized in WHIV.