Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection | Zendy

Estelle Chiari | Zendy; Jason Weiss | Zendy; Michael R. Simon | Zendy; S.T. Kießig | Zendy; Mark Pulse | Zendy; Stephen Brown | Zendy; Hanne R Gerding | Zendy; Maurice Mandago | Zendy; Karina Gisch | Zendy; Christoph von EichelStreiber | Zendy

Open Access

Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

Author(s) -

Estelle Chiari,

Jason Weiss,

Michael R. Simon,

S.T. Kießig,

Mark Pulse,

Stephen Brown,

Hanne R Gerding,

Maurice Mandago,

Karina Gisch,

Christoph von EichelStreiber

Publication year - 2021

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiab087

Subject(s) - hamster , mesocricetus , immunoglobulin a , clostridioides , immunology , antibody , vancomycin , microbiology and biotechnology , immunization , medicine , immunoglobulin g , biology , pharmacology , bacteria , genetics , staphylococcus aureus

Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P = .018 and .039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.

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