Open AccessMethylome-wide Analysis Reveals Epigenetic Marks Associated With Resistance to Tuberculosis in Human Immunodeficiency Virus–Infected Individuals From East Africa
Author(s) -
Catherine M. Stein,
Penelope Benchek,
Jacquelaine Bartlett,
Robert P. Igo,
Rafal S. Sobota,
Keith Chervenak,
Harriet MayanjaKizza,
C. Fordham von Reyn,
Timothy Lahey,
William S. Bush,
W. Henry Boom,
William K. Scott,
Carmen J. Marsit,
Giorgio Sirugo,
Scott M. Williams
Publication year - 2021
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa785
Subject(s) - epigenetics , genome wide association study , biology , tuberculosis , single nucleotide polymorphism , dna methylation , mycobacterium tuberculosis , genetics , methylation , virology , immunology , gene , medicine , genotype , gene expression , pathology
Tuberculosis (TB) is the most deadly infectious disease globally and is highly prevalent in the developing world. For individuals infected with both Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV), the risk of active TB is 10% or more annually. Previously, we identified in a genome-wide association study (GWAS) a region on chromosome 5 associated with resistance to TB, which included epigenetic marks that could influence gene regulation. We hypothesized that HIV-infected individuals exposed to Mtb who remain disease free carry epigenetic changes that strongly protect them from active TB.