Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019 | Zendy

AnneSophie Bedin | Zendy; Alain Makinson | Zendy; MarieChristine Picot | Zendy; Frank Mennechet | Zendy; Fabrice Malergue | Zendy; Amandine Pisoni | Zendy; Esperance Nyiramigisha | Zendy; Lise Montagnier | Zendy; Karine Bolloré | Zendy; Ségolène Debiesse | Zendy; David Morquin | Zendy; P Bourgoin | Zendy; Nicolas Veyrenche | Zendy; Constance Renault | Zendy; Vincent Foulongne | Zendy; Caroline Bret | Zendy; Arnaud Bourdin | Zendy; Vincent Le Moing | Zendy; Philippe Van de Perre | Zendy; Édouard Tuaillon | Zendy

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Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

Author(s) -

AnneSophie Bedin,

Alain Makinson,

MarieChristine Picot,

Frank Mennechet,

Fabrice Malergue,

Amandine Pisoni,

Esperance Nyiramigisha,

Lise Montagnier,

Karine Bolloré,

Ségolène Debiesse,

David Morquin,

P Bourgoin,

Nicolas Veyrenche,

Constance Renault,

Vincent Foulongne,

Caroline Bret,

Arnaud Bourdin,

Vincent Le Moing,

Philippe Van de Perre,

Édouard Tuaillon

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa724

Subject(s) - monocyte , medicine , outbreak , coronavirus , biomarker , covid-19 , immunology , disease , triage , cytokine storm , virology , biology , infectious disease (medical specialty) , emergency medicine , biochemistry

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

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