Open AccessNative Human Antibody to Shr Promotes Mice Survival After Intraperitoneal Challenge With Invasive Group A Streptococcus
Author(s) -
Nilanjana Chatterjee,
Ya Shu Huang,
Kristin V. Lyles,
Julie Morgan,
Lawrence M. Kauvar,
Susanna F. Greer,
Zehava Eichenbaum
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa540
Subject(s) - monoclonal antibody , streptococcus pyogenes , antibody , streptococcus , heme , hemoglobin , vaccination , immunization , in vitro , immunology , immunotherapy , microbiology and biotechnology , medicine , biology , pharmacology , immune system , bacteria , biochemistry , enzyme , genetics , staphylococcus aureus
A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclonal antibodies (mAbs) against Shr and evaluated their efficacy and mechanism.