Open AccessOrally Administered Bacillus Spores Expressing an Extracellular Vesicle-Derived Tetraspanin Protect Hamsters Against Challenge Infection With Carcinogenic Human Liver Fluke
Author(s) -
Wuttipong Phumrattanaprapin,
Sujittra Chaiyadet,
Paul J Brindley,
Mark S. Pearson,
Michael Smout,
Alex Loukas,
Thewarach Laha
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa516
Subject(s) - opisthorchis viverrini , biology , liver fluke , tetraspanin , mesocricetus , microbiology and biotechnology , praziquantel , bile duct , immunology , opisthorchiasis , recombinant dna , clonorchis sinensis , hamster , virology , pathology , medicine , cell , helminths , biochemistry , schistosomiasis , gene
The human liver fluke Opisthorchis viverrini is a food-borne trematode that causes hepatobiliary disease in humans throughout Southeast Asia. People become infected by consuming raw or undercooked fish containing metacercariae. Development of a vaccine to prevent or minimize pathology would decrease the risk of severe morbidity, including the development of bile duct cancer.