Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients | Zendy

María Teresa Schiaffino | Zendy; Marisa Di Natale | Zendy; Elena GarcíaMartínez | Zendy; J. Navarro | Zendy; José Luis MuñozBlanco | Zendy; Pablo DemeloRodríguez | Zendy; Paloma SánchezMateos | Zendy

Open Access

Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients

Author(s) -

María Teresa Schiaffino,

Marisa Di Natale,

Elena GarcíaMartínez,

J. Navarro,

José Luis MuñozBlanco,

Pablo DemeloRodríguez,

Paloma SánchezMateos

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa485

Subject(s) - autoantibody , seroconversion , medicine , covid-19 , coronavirus , clinical significance , immunofluorescence , gastroenterology , pathology , antibody , disease , immunology , infectious disease (medical specialty)

Background During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients. Methods The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections. Results We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion. Conclusions Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.

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