Open AccessAn Inflammatory Composite Score Predicts Mycobacterial Immune Reconstitution Inflammatory Syndrome in People with Advanced HIV: A Prospective International Cohort Study
Author(s) -
Caian L. Vinhaes,
Virginia Sheikh,
Deivide Oliveira-de-Souza,
Jing Wang,
Adam Rupert,
Gregg Roby,
María B. Arriaga,
Kiyoshi F. Fukutani,
Fred Sawe,
Doug Shaffer,
Jintanat Ananworanich,
Nittaya Phanuphak,
Bruno B. Andrade,
Irini Sereti
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa484
Subject(s) - immune reconstitution inflammatory syndrome , medicine , immunology , cohort , immunosuppression , procalcitonin , prospective cohort study , cohort study , viral load , antiretroviral therapy , virus , sepsis
Immune reconstitution inflammatory syndrome (IRIS) is a common cause of morbidity among people with human immunodeficiency virus (PWH) who initiate antiretroviral therapy (ART) with severe lymphopenia. Easily accessible tools that reliably predict emergence and elucidate pathogenesis of IRIS are needed to facilitate improved clinical management.