Open AccessAlcohol Use Is Associated With Intestinal Dysbiosis and Dysfunctional CD8+ T-Cell Phenotypes in Persons With Human Immunodeficiency Virus
Author(s) -
Vincent J. Maffei,
Robert W. Siggins,
Meng Luo,
Meghan Brashear,
Donald E. Mercante,
Christopher M. Taylor,
Patricia E. Molina,
David A. Welsh
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa461
Subject(s) - dysbiosis , immunology , cd8 , phosphatidylethanol , biology , alcohol use disorders identification test , alcohol , gut flora , immune system , genetics , alcohol consumption , phospholipid , biochemistry , membrane , phosphatidylcholine
Inflammation persists among persons with human immunodeficiency virus (PWH) despite effective antiretroviral therapy and may contribute to T-cell dysfunction. Alcohol use is prevalent among PWH and promotes intestinal leak, dysbiosis, and a proinflammatory milieu. Whether alcohol use is associated with T-cell late differentiation remains to be investigated.