Open AccessAnalysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres
Author(s) -
Wentao Chen,
David Šmajs,
Yongfei Hu,
Wujian Ke,
Petra Pospíšilová,
Kelly L. Hawley,
Melissa J. Caimano,
Justin D. Radolf,
Arlene C. Seña,
Joseph D. Tucker,
Bin Yang,
Jonathan J. Juliano,
Heping Zheng,
Jonathan B. Parr
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa449
Subject(s) - treponema , chancre , whole genome sequencing , biology , syphilis , genome , virology , subspecies , reference genome , genetics , gene , human immunodeficiency virus (hiv) , paleontology
Whole-genome sequencing (WGS) of Treponema pallidum subspecies pallidum (TPA) has been constrained by the lack of in vitro cultivation methods for isolating spirochetes from patient samples.