Open AccessEpstein-Barr Virus-Based Nasopharyngeal Carcinoma (NPC) Risk Prediction Scores Are Elevated in NPC Multiplex Family Members in Taiwan
Author(s) -
Hsuan-Shu Lee,
Yu Jie Huang,
Anna E. Coghill,
Zhiwei Liu,
Kelly J. Yu,
Wei-Li Hsu,
Yen-Wei Chien,
Cheng-Ping Wang,
TsengCheng Chen,
Chien Jen Chen,
Allan Hildesheim
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa385
Subject(s) - nasopharyngeal carcinoma , multiplex , population , epstein–barr virus , virus , case control study , oncology , immunology , biology , virology , medicine , genetics , environmental health , radiation therapy
Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control.