Steep Rebound of Chloroquine-SensitivePlasmodium falciparumin Zimbabwe | Zendy

Sungano Mharakurwa | Zendy; Zvifadzo Matsena Zingoni | Zendy; Nobert Mudare | Zendy; Charmaine Matimba | Zendy; Tanatswa Xuxa Gara | Zendy; Aramu Makuwaza | Zendy; Gladys Maponga | Zendy; Shungu Munyati | Zendy; Lovemore Gwanzura | Zendy; Susan Mutambu | Zendy; Peter Mason | Zendy; Tamaki Kobayashi | Zendy; Nicholas Midzi | Zendy; William J. Moss | Zendy; Matthew M. Ippolito | Zendy

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Steep Rebound of Chloroquine-SensitivePlasmodium falciparumin Zimbabwe

Author(s) -

Sungano Mharakurwa,

Zvifadzo Matsena Zingoni,

Nobert Mudare,

Charmaine Matimba,

Tanatswa Xuxa Gara,

Aramu Makuwaza,

Gladys Maponga,

Shungu Munyati,

Lovemore Gwanzura,

Susan Mutambu,

Peter Mason,

Tamaki Kobayashi,

Nicholas Midzi,

William J. Moss,

Matthew M. Ippolito

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa368

Subject(s) - chloroquine , malaria , plasmodium falciparum , discontinuation , drug resistance , medicine , drug , formulary , pharmacology , virology , biology , immunology , microbiology and biotechnology

Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.

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