Open AccessPredicting Vibrio cholerae Infection and Disease Severity Using Metagenomics in a Prospective Cohort Study
Author(s) -
Inès Levade,
Morteza M. Saber,
Firas S Midani,
Fahima Chowdhury,
Ashraful Islam Khan,
Yasmin Begum,
Edward T. Ryan,
Lawrence A. David,
Stephen B. Calderwood,
Jason B. Harris,
Regina C. LaRocque,
Firdausi Qadri,
Ben Shapiro,
Ana A. Weil
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa358
Subject(s) - metagenomics , vibrio cholerae , biology , microbiome , prevotella , shotgun sequencing , deep sequencing , disease , ribosomal rna , microbiology and biotechnology , dna sequencing , genetics , gene , medicine , genome , bacteria
Susceptibility to Vibrio cholerae infection is affected by blood group, age, and preexisting immunity, but these factors only partially explain who becomes infected. A recent study used 16S ribosomal RNA amplicon sequencing to quantify the composition of the gut microbiome and identify predictive biomarkers of infection with limited taxonomic resolution.