Predicting Vibrio cholerae Infection and Disease Severity Using Metagenomics in a Prospective Cohort Study | Zendy

Inès Levade | Zendy; Morteza M. Saber | Zendy; Firas S. Midani | Zendy; Fahima Chowdhury | Zendy; Ashraful Islam Khan | Zendy; Yasmin Ara Begum | Zendy; Edward T. Ryan | Zendy; Lawrence A. David | Zendy; Stephen B. Calderwood | Zendy; Jason B. Harris | Zendy; Regina C. LaRocque | Zendy; Firdausi Qadri | Zendy; B. Jesse Shapiro | Zendy; Ana A. Weil | Zendy

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Predicting Vibrio cholerae Infection and Disease Severity Using Metagenomics in a Prospective Cohort Study

Author(s) -

Inès Levade,

Morteza M. Saber,

Firas S. Midani,

Fahima Chowdhury,

Ashraful Islam Khan,

Yasmin Ara Begum,

Edward T. Ryan,

Lawrence A. David,

Stephen B. Calderwood,

Jason B. Harris,

Regina C. LaRocque,

Firdausi Qadri,

B. Jesse Shapiro,

Ana A. Weil

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa358

Subject(s) - metagenomics , vibrio cholerae , biology , microbiome , prevotella , shotgun sequencing , cholera vaccine , deep sequencing , microbiology and biotechnology , dna sequencing , gene , genetics , genome , bacteria

Susceptibility to Vibrio cholerae infection is affected by blood group, age, and preexisting immunity, but these factors only partially explain who becomes infected. A recent study used 16S ribosomal RNA amplicon sequencing to quantify the composition of the gut microbiome and identify predictive biomarkers of infection with limited taxonomic resolution.

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