Mechanistic Insights Into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium | Zendy

Razieh Kebriaei | Zendy; Kyle Stamper | Zendy; Kavindra V. Singh | Zendy; Ayesha Khan | Zendy; Seth Rice | Zendy; An Q Dinh | Zendy; Truc T. Tran | Zendy; Barbara E. Murray | Zendy; César A. Arias | Zendy; Michael J. Rybak | Zendy

Open Access

Mechanistic Insights Into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium

Author(s) -

Razieh Kebriaei,

Kyle Stamper,

Kavindra V. Singh,

Ayesha Khan,

Seth Rice,

An Q Dinh,

Truc T. Tran,

Barbara E. Murray,

César A. Arias,

Michael J. Rybak

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa319

Subject(s) - daptomycin , enterococcus faecium , penicillin binding proteins , biology , microbiology and biotechnology , penicillin , cephalosporin , antibiotics , staphylococcus aureus , vancomycin , bacteria , genetics

The combination of daptomycin (DAP) plus ampicillin (AMP), ertapenem (ERT), or ceftaroline has been demonstrated to be efficacious against a DAP-tolerant Enterococcus faecium strain (HOU503). However, the mechanism for the efficacy of these combinations against DAP-resistant (DAP-R) E. faecium strains is unknown.

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