Open AccessMechanistic Insights Into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium
Author(s) -
Razieh Kebriaei,
Kyle Stamper,
Kavindra V. Singh,
Ayesha Khan,
Seth Rice,
An Q Dinh,
Truc T. Tran,
Barbara E. Murray,
César A. Arias,
Michael J. Rybak
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa319
Subject(s) - daptomycin , enterococcus faecium , penicillin binding proteins , biology , microbiology and biotechnology , penicillin , cephalosporin , antibiotics , staphylococcus aureus , vancomycin , bacteria , genetics
The combination of daptomycin (DAP) plus ampicillin (AMP), ertapenem (ERT), or ceftaroline has been demonstrated to be efficacious against a DAP-tolerant Enterococcus faecium strain (HOU503). However, the mechanism for the efficacy of these combinations against DAP-resistant (DAP-R) E. faecium strains is unknown.