Open AccessInhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease
Author(s) -
Sarah M. Beno,
Ashleigh N. Riegler,
Ryan P. Gilley,
Terry Brissac,
Yong Wang,
Katherine L. Kruckow,
Jeevan Kumar Jadapalli,
Griffin Wright,
Anukul T. Shenoy,
Sara N. Stoner,
Marcos I. Restrepo,
Jessy Deshane,
Ganesh V. Halade,
Norberto González-Juarbe,
Carlos J. Orihuela
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa295
Subject(s) - necroptosis , medicine , pneumolysin , immunology , pathology , programmed cell death , biology , streptococcus pneumoniae , microbiology and biotechnology , antibiotics , apoptosis , biochemistry
Streptococcus pneumoniae infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a proinflammatory form of cell death instigated by pore-forming toxins such as S. pneumoniae pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage during invasive pneumococcal disease (IPD).