MicroRNA Signature of Epithelial-Mesenchymal Transition in Group B Streptococcal Infection of the Placental Chorioamniotic Membranes | Zendy

Samantha Weed | Zendy; Blair Armistead | Zendy; Michelle M. Coleman | Zendy; H Denny Liggit | Zendy; Brian Johnson | Zendy; Jesse Tsai | Zendy; Richard P. Beyer | Zendy; Theodor K. Bammler | Zendy; Nicole M. Kretzer | Zendy; Ed Parker | Zendy; Jeroen Vanderhoeven | Zendy; Craig J. Bierle | Zendy; Lakshmi Rajagopal | Zendy; Kristina M. Adams Waldorf | Zendy

Open Access

MicroRNA Signature of Epithelial-Mesenchymal Transition in Group B Streptococcal Infection of the Placental Chorioamniotic Membranes

Author(s) -

Samantha Weed,

Blair Armistead,

Michelle M. Coleman,

H Denny Liggit,

Brian Johnson,

Jesse Tsai,

Richard P. Beyer,

Theodor K. Bammler,

Nicole M. Kretzer,

Ed Parker,

Jeroen Vanderhoeven,

Craig J. Bierle,

Lakshmi Rajagopal,

Kristina M. Adams Waldorf

Publication year - 2020

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiaa280

Subject(s) - amnion , medicine , fetal membrane , vimentin , mesenchymal stem cell , chorioamnionitis , premature rupture of membranes , placenta , pregnancy , pathology , andrology , fetus , immunohistochemistry , biology , genetics

Infection-induced preterm birth is a major cause of neonatal mortality and morbidity and leads to preterm premature rupture of placental chorioamniotic membranes. The loss of amniotic epithelial cells and tensile strength preceding membrane rupture is poorly understood. We hypothesized that intrauterine bacterial infection induces changes in microRNA (miRNA) expression, leading to amniotic epithelial cell loss and membrane weakening.

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