Open AccessMicroRNA Signature of Epithelial-Mesenchymal Transition in Group B Streptococcal Infection of the Placental Chorioamniotic Membranes
Author(s) -
Samantha Weed,
Blair Armistead,
Michelle Coleman,
H Denny Liggit,
Brian Johnson,
Jesse Tsai,
Richard P. Beyer,
Theodor K. Bämmler,
Nicole M. Kretzer,
Ed Parker,
Jeroen Vanderhoeven,
Craig J. Bierle,
Lakshmi Rajagopal,
Kristina M. Adams Waldorf
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa280
Subject(s) - amnion , fetal membrane , medicine , vimentin , chorioamnionitis , premature rupture of membranes , mesenchymal stem cell , amniotic fluid , placenta , pregnancy , pathology , andrology , biology , fetus , immunohistochemistry , genetics
Infection-induced preterm birth is a major cause of neonatal mortality and morbidity and leads to preterm premature rupture of placental chorioamniotic membranes. The loss of amniotic epithelial cells and tensile strength preceding membrane rupture is poorly understood. We hypothesized that intrauterine bacterial infection induces changes in microRNA (miRNA) expression, leading to amniotic epithelial cell loss and membrane weakening.