Open AccessPneumocystis carinii Major Surface Glycoprotein Dampens Macrophage Inflammatory Responses to Fungal β-Glucan
Author(s) -
Theodore J. Kottom,
Deanne Hebrink,
Eva M. Carmona,
Andrew H. Limper
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa218
Subject(s) - biology , immune system , proinflammatory cytokine , tumor necrosis factor alpha , pneumocystis carinii , microbiology and biotechnology , downregulation and upregulation , macrophage , glycoprotein , pattern recognition receptor , inflammation , immunology , innate immune system , biochemistry , in vitro , gene , human immunodeficiency virus (hiv) , pneumocystis jirovecii
Pneumocystis major surface glycoprotein (Msg) is a 120-kD surface protein complex on the organism with importance in adhesion and immune recognition. In this study, we show that Msg significantly impairs tumor necrosis factor (TNF)-α secretion by macrophages induced by Saccharomyces cerevisiae and Pneumocystis carinii (Pc) β-glucans.