Open AccessPrimary and Secondary Dengue Virus Infections Elicit Similar Memory B-Cell Responses, but Breadth to Other Serotypes and Cross-Reactivity to Zika Virus Is Higher in Secondary Dengue
Author(s) -
Paulina Andrade,
Parnal Narvekar,
Magelda Montoya,
Daniela Michlmayr,
Ángel Balmaseda,
Joséfina Coloma,
Eva Harris
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiaa120
Subject(s) - dengue virus , dengue fever , zika virus , serotype , virology , biology , virus , flavivirus , immunology
The 4 antigenically distinct serotypes of dengue virus (DENV) share extensive homology with each other and with the closely related Zika flavivirus (ZIKV). The development of polyclonal memory B cells (MBCs) to the 4 DENV serotypes and ZIKV during DENV infection is not fully understood.