Open AccessInhibition of Monoacylglycerol Lipase Reduces the Reinstatement of Methamphetamine-Seeking and Anxiety-Like Behaviors in Methamphetamine Self-Administered Rats
Author(s) -
Yoko Nawata,
Taku Yamaguchi,
Ryo Fukumori,
Tsuneyuki Yamamoto
Publication year - 2018
Publication title -
international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyy086
Subject(s) - methamphetamine , fatty acid amide hydrolase , self administration , pharmacology , monoacylglycerol lipase , anandamide , endocannabinoid system , cannabinoid receptor , am251 , cannabinoid , psychology , antagonist , chemistry , medicine , receptor , biochemistry
Methamphetamine is a highly addictive psychostimulant with reinforcing properties. Our laboratory previously found that Δ8-tetrahydrocannabinol, an exogenous cannabinoid, suppressed the reinstatement of methamphetamine-seeking behavior. The purpose of this study was to determine whether the elevation of endocannabinoids modulates the reinstatement of methamphetamine-seeking behavior and emotional changes in methamphetamine self-administered rats.