Open AccessBirthweight in offspring and cardiovascular mortality in their parents, aunts and uncles: a family-based cohort study of 1.35 million births
Author(s) -
Fareeha Shaikh,
Marte Karoline Kjølllesdal,
David Carslake,
Camilla Stoltenberg,
George Davey Smith,
Øyvind Næss
Publication year - 2019
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyz156
Subject(s) - offspring , medicine , demography , norwegian , hazard ratio , cohort , cohort study , pregnancy , pediatrics , gerontology , confidence interval , genetics , biology , linguistics , philosophy , sociology
A link between suboptimal fetal growth and higher risk of cardiovascular disease (CVD) is well documented. It has been difficult to assess the contribution of environmental versus genetic factors to the association, as these factors are closely connected in nuclear families. We investigated the association between offspring birthweight and CVD mortality in parents, aunts and uncles, and examined whether these associations are explained by CVD risk factors.