Open AccessRepurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study
Author(s) -
Venexia Walker,
Patrick Gavin Kehoe,
Richard M. Martin,
Neil M Davies
Publication year - 2019
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyz155
Subject(s) - mendelian randomization , blood pressure , medicine , single nucleotide polymorphism , antihypertensive drug , odds ratio , confounding , disease , confidence interval , randomization , cardiology , bioinformatics , randomized controlled trial , genetics , biology , gene , genotype , genetic variants
Evidence concerning the potential repurposing of antihypertensives for Alzheimer's disease prevention is inconclusive. We used Mendelian randomization, which can be more robust to confounding by indication and patient characteristics, to investigate the effects of lowering systolic blood pressure, via the protein targets of different antihypertensive drug classes, on Alzheimer's disease.