Open AccessShort Disease Duration Is Associated With Increased Risk of Treatment Failure in Biologic-Treated Patients With Ulcerative Colitis
Author(s) -
Nghia Nguyen,
Soumya Kurnool,
Parambir S. Dulai,
Brigid S. Boland,
William J. Sandborn,
Siddharth Singh
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz276
Subject(s) - medicine , interquartile range , ulcerative colitis , hazard ratio , inflammatory bowel disease , discontinuation , proportional hazards model , odds ratio , retrospective cohort study , confidence interval , disease , colectomy , surgery , gastroenterology
Longer disease duration is associated with inferior response to biologic therapy in Crohn's disease. However, the effect of disease duration on response to biologic therapy in ulcerative colitis (UC) has not been well studied.