All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation | Zendy

Shubha Priyamvada | Zendy; Arivarasu Natarajan Anbazhagan | Zendy; Anoop Kumar | Zendy; Ishita Chatterjee | Zendy; Alip Borthakur | Zendy; Seema Saksena | Zendy; Ravinder K. Gill | Zendy; Waddah A. Alrefai | Zendy; Pradeep K. Dudeja | Zendy

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All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation

Author(s) -

Shubha Priyamvada,

Arivarasu Natarajan Anbazhagan,

Anoop Kumar,

Ishita Chatterjee,

Alip Borthakur,

Seema Saksena,

Ravinder K. Gill,

Waddah A. Alrefai,

Pradeep K. Dudeja

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz249

Subject(s) - retinoic acid , colitis , inflammation , in vivo , downregulation and upregulation , chemistry , immunology , biology , medicine , pharmacology , cancer research , cell culture , biochemistry , microbiology and biotechnology , gene , genetics

Intestinal epithelial apical membrane Cl-/HCO3- exchanger DRA (downregulated in adenoma, SLC26A3) has emerged as an important therapeutic target for diarrhea, emphasizing the potential therapeutic role of agents that upregulate DRA. All-trans retinoic acid (ATRA), a key vitamin A metabolite, was earlier shown by us to stimulate DRA expression in intestinal epithelial cells. However, its role in modulating DRA in gut inflammation has not been investigated.

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