Open AccessAll-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation
Author(s) -
Shubha Priyamvada,
Arivarasu Natarajan Anbazhagan,
Anoop Kumar,
Ishita Chatterjee,
Alip Borthakur,
Seema Saksena,
Ravinder K. Gill,
Waddah A. Alrefai,
Pradeep K. Dudeja
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz249
Subject(s) - retinoic acid , colitis , downregulation and upregulation , inflammation , in vivo , tumor necrosis factor alpha , chemistry , immunology , biology , medicine , biochemistry , microbiology and biotechnology , gene
Intestinal epithelial apical membrane Cl-/HCO3- exchanger DRA (downregulated in adenoma, SLC26A3) has emerged as an important therapeutic target for diarrhea, emphasizing the potential therapeutic role of agents that upregulate DRA. All-trans retinoic acid (ATRA), a key vitamin A metabolite, was earlier shown by us to stimulate DRA expression in intestinal epithelial cells. However, its role in modulating DRA in gut inflammation has not been investigated.