Does Reverse Causality Underlie the Temporal Relationship Between Depression and Crohn’s Disease? | Zendy

Lawrence S. Gaines | Zendy; James C. Slaughter | Zendy; David A. Schwartz | Zendy; Dawn B. Beaulieu | Zendy; Sara Horst | Zendy; Robin Dalal | Zendy; Elizabeth Scoville | Zendy; Robert S. Sandler | Zendy; Michael D. Kappelman | Zendy

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Does Reverse Causality Underlie the Temporal Relationship Between Depression and Crohn’s Disease?

Author(s) -

Lawrence S. Gaines,

James C. Slaughter,

David A. Schwartz,

Dawn B. Beaulieu,

Sara Horst,

Robin Dalal,

Elizabeth Scoville,

Robert S. Sandler,

Michael D. Kappelman

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz123

Subject(s) - depression (economics) , causality (physics) , cognition , psychology , converse , disease , clinical psychology , crohn's disease , medicine , psychiatry , mathematics , physics , geometry , quantum mechanics , economics , macroeconomics

Studies suggest that there is a temporal relationship between depression and Crohn's disease (CD) activity. However, these studies assumed a unidirectional relationship and did not examine the possibility of reverse causality and the risk of a spurious association due to the overlap of symptoms underlying the depression-CD relationship. We evaluated the existence of reverse causality reflected in a possible bidirectional relationship between patient-reported CD activity and an affective-cognitive dimension of depression.

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