Open AccessStreptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn’s Disease?
Author(s) -
Rishi Goel,
Erica M. Prosdocimi,
Ariella Amar,
Yasmin Omar,
Michael Escudier,
Jeremy Sanderson,
William Wade,
Natalie J. Prescott
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz022
Subject(s) - streptococcus salivarius , lactobacillus salivarius , saliva , streptococcus mitis , streptococcus , crohn's disease , disease , immunology , medicine , oral microbiome , pathogenesis , microbiology and biotechnology , biology , bacteria , lactobacillus , genetics
Orofacial granulomatosis (OFG) is a rare disease characterised by chronic, noncaseating, granulomatous inflammation primarily affecting the oral cavity. Histologically, it is similar to Crohn's disease (CD), and a proportion of patients have both OFG and CD. The cause of OFG remains elusive, but it has been suggested that microbial interactions may be involved. The aim of this study was to compare the salivary microbial composition of subjects with OFG and/or CD and healthy controls.