Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-α Overexpression in Crohn Disease–Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells | Zendy

R Brückner | Zendy; Marianne R. Spalinger | Zendy; Marieke C. Barnhoorn | Zendy; Roger Feakins | Zendy; Alois Fuerst | Zendy; E. C. Jehle | Zendy; Andreas Rickenbacher | Zendy; Matthias Turina | Zendy; Aniechcial | Zendy; Silvia Lang | Zendy; Lukas J.A.C. Hawinkels | Zendy; Andrea E. van der Meulen–de Jong | Zendy; Hein W. Verspaget | Zendy; Gerhard Rogler | Zendy; Michael Scharl | Zendy

Open Access

Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-α Overexpression in Crohn Disease–Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells

Author(s) -

R Brückner,

Marianne R. Spalinger,

Marieke C. Barnhoorn,

Roger Feakins,

Alois Fuerst,

E. C. Jehle,

Andreas Rickenbacher,

Matthias Turina,

Aniechcial,

Silvia Lang,

Lukas J.A.C. Hawinkels,

Andrea E. van der Meulen–de Jong,

Hein W. Verspaget,

Gerhard Rogler,

Michael Scharl

Publication year - 2020

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izaa240

Subject(s) - cd8 , cd3 , tumor necrosis factor alpha , cytokine , perianal abscess , cytotoxic t cell , medicine , immunology , biology , fistula , cancer research , immune system , surgery , in vitro , biochemistry

Fistulas represent a frequent and severe complication in patients with Crohn disease (CD). Tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta, and interleukin (IL)-13 are known to trigger epithelial-mesenchymal transition (EMT), promoting fistula formation. Here, we investigated the role of T-lymphocytes (T cells) in fistula pathogenesis.

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