Open AccessCrohn’s Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria
Author(s) -
Nur M Shahir,
Jeremy Wang,
Elisabeth A. Wolber,
Matthew Schaner,
Daniel N. Frank,
Diana Ir,
Charles E. Robertson,
Nicole Chaumont,
Timothy S. Sadiq,
Mark J. Koruda,
Reza Rahbar,
Billy D. Nix,
Rodney D. Newberry,
R. Balfour Sartor,
Shehzad Z. Sheikh,
Terrence S. Furey
Publication year - 2020
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izaa103
Subject(s) - obligate anaerobe , ileum , bacteroides , biology , bacteroides fragilis , microbiome , bacteria , microbiology and biotechnology , proteobacteria , obligate , gut flora , inflammatory bowel disease , bacteroidaceae , disease , immunology , 16s ribosomal rna , pathology , ecology , medicine , antibiotics , genetics , biochemistry
The intestinal microbiota play a key role in the onset, progression, and recurrence of Crohn disease (CD). Most microbiome studies assay fecal material, which does not provide region-specific information on mucosally adherent bacteria that directly interact with host systems. Changes in luminal oxygen have been proposed as a contributor to CD dybiosis.