Open AccessCumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study
Author(s) -
Olivia V. Yvellez,
Victoria Rai,
Philip H. Sossenheimer,
John Hart,
Jerrold R. Turner,
Christopher Weber,
Katia El Jurdi,
David T. Rubin
Publication year - 2020
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izaa047
Subject(s) - ulcerative colitis , medicine , dysplasia , gastroenterology , cohort , colorectal cancer , inflammation , inflammatory bowel disease , confidence interval , colitis , cancer , disease
Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A group at St. Mark's Hospital reported a novel cumulative inflammatory index that predicted the development of CRN in UC patients that we validated with an independent, well-described, matched, case-controlled cohort from the University of Chicago.