Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis | Zendy

Tharu Tharakan | Zendy; Giovanni Corona | Zendy; Daniel Foran | Zendy; Andrea Salonia | Zendy; Nikolaos Sofikitis | Zendy; Aleksander Giwercman | Zendy; Csilla Krausz | Zendy; Tet Yap | Zendy; Chan. Jayasena | Zendy; Suks Minhas | Zendy

Open Access

Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis

Author(s) -

Tharu Tharakan,

Giovanni Corona,

Daniel Foran,

Andrea Salonia,

Nikolaos Sofikitis,

Aleksander Giwercman,

Csilla Krausz,

Tet Yap,

Chan. Jayasena,

Suks Minhas

Publication year - 2022

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmac016

Subject(s) - medicine , sperm retrieval , azoospermia , meta analysis , cochrane library , hormonal therapy , testicular sperm extraction , gynecology , infertility , pregnancy , prostate cancer , biology , genetics , cancer

The beneficial effects of hormonal therapy in stimulating spermatogenesis in patients with non-obstructive azoospermia (NOA) and either normal gonadotrophins or hypergonadotropic hypogonadism prior to surgical sperm retrieval (SSR) is controversial. Although the European Association of Urology guidelines state that hormone stimulation is not recommended in routine clinical practice, a significant number of patients undergo empiric therapy prior to SSR. The success rate for SSR from microdissection testicular sperm extraction is only 40-60%, thus hormonal therapy could prove to be an effective adjunctive therapy to increase SSR rates.

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