Open AccessNewly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts
Author(s) -
Xiaohui Hu,
Qi Zhu,
Yan Wang,
Liling Wang,
Zhihui Li,
Gil Mor,
Aihua Liao
Publication year - 2020
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deaa223
Subject(s) - decidua , flow cytometry , placenta , biology , andrology , immunology , recurrent miscarriage , western blot , decidual cells , pregnancy , miscarriage , medicine , fetus , biochemistry , genetics , gene
What is the mechanism of Tim-3+ regulatory T (Treg)-cell accumulation in the decidua during early pregnancy and is its disruption associated with recurrent pregnancy loss (RPL)?