English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel  cis- eQTLs and  trans- eQTLs. Mediation testing and colocalization analysis demonstrate that  MSMB  is a  cis -acting mediator for  SNHG11  ( P  &lt; 0.01). Removing rs10993994 in LNCaP cell lines by CRISPR/Cas9 editing shows that the C-allele corresponds with an over 100-fold increase in  MSMB  expression and 5-fold increase in  SNHG11  compared with the T-allele. Colocalization analysis confirmed that the same set of SNPs associated with  MSMB  expression is associated with  SNHG11  expression (posterior probability of shared variants is 66.6% in tumor and 91.4% in benign). These analyses further demonstrate variants driving  MSMB  expression differ in tumor and normal, suggesting regulatory network rewiring during tumorigenesis.

Prostate cancer risk SNP rs10993994 is a trans -eQTL for SNHG11 mediated through MSMB