Open AccessSmcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models
Author(s) -
Liang Chen,
Qiang Shao,
Wei Zhang,
Mei Yang,
Qing Chang,
Rong Chen,
JianFu Chen
Publication year - 2020
Publication title -
human molecular genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.811
H-Index - 276
eISSN - 1460-2083
pISSN - 0964-6906
DOI - 10.1093/hmg/ddaa012
Subject(s) - c9orf72 , haploinsufficiency , downregulation and upregulation , axoplasmic transport , amyotrophic lateral sclerosis , frontotemporal dementia , biology , neuroscience , autophagy , microbiology and biotechnology , knockout mouse , genetically modified mouse , transgene , pathology , medicine , phenotype , disease , dementia , genetics , gene , apoptosis
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