Open AccessTranscriptAchilles: a genome-wide platform to predict isoform biomarkers of gene essentiality in cancer
Author(s) -
Fernando Carazo,
Lucía Campuzano,
Xabier Cendoya,
Francisco J Planes,
Ángel Rubio
Publication year - 2019
Publication title -
gigascience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.947
H-Index - 54
ISSN - 2047-217X
DOI - 10.1093/gigascience/giz021
Subject(s) - computational biology , gene isoform , genome , gene , biology , cancer biomarkers , cancer , genetics , bioinformatics
Aberrant alternative splicing plays a key role in cancer development. In recent years, alternative splicing has been used as a prognosis biomarker, a therapy response biomarker, and even as a therapeutic target. Next-generation RNA sequencing has an unprecedented potential to measure the transcriptome. However, due to the complexity of dealing with isoforms, the scientific community has not sufficiently exploited this valuable resource in precision medicine.