Open AccessTARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
Author(s) -
Viviana Pérez
Publication year - 2019
Publication title -
innovation in aging
Language(s) - English
Resource type - Journals
ISSN - 2399-5300
DOI - 10.1093/geroni/igz038.1349
Subject(s) - pi3k/akt/mtor pathway , regulator , key (lock) , discovery and development of mtor inhibitors , biology , microbiology and biotechnology , signal transduction , neuroscience , medicine , cancer research , ecology , genetics , gene
The mechanistic target of rapamycin (mTOR) is a key nutrient and growth factor-responsive pathway that has emerged as a central regulator of aging. Inhibition of mTOR complex I in particular has been found to increase lifespan and improve functional declines during aging in yeast, worms, flies, and mice. Recently clinical studies have provided the first evidence that similar effects may be achievable in pet dogs and in elderly people. This session will focus on new discoveries related to mTOR signaling and aging.