Open AccessParental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease
Author(s) -
Bessie C Stamm,
Patrick J. Lao,
Batool Rizvi,
Juliet M. Colón,
Kay C. Igwe,
Anthony G. Chesebro,
Benjamin Maas,
Nicole Schupf,
Richard Mayeux,
Jennifer J. Manly,
Adam M. Brickman
Publication year - 2019
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glz291
Subject(s) - dementia , family history , sibling , hyperintensity , medicine , disease , magnetic resonance imaging , medical history , psychology , pediatrics , developmental psychology , radiology
Small vessel cerebrovascular dysfunction that manifests on magnetic resonance imaging (MRI) as white matter hyperintensities (WMH) is linked to increased risk and progression of Alzheimer's disease (AD), but there is considerable debate about whether it represents a core feature of the disease. Parental history of dementia is a risk factor for AD, suggesting a strong heritable component; the examination of the extent to which parental history of dementia is associated with cerebrovascular disease could provide insight into the aggregation of AD and cerebrovascular disease.