Open AccessAccelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology
Author(s) -
Anne B. Newman,
Stephen B. Kritchevsky,
Jack M. Guralnik,
Steven R. Cummings,
Marcel E. Salive,
George A. Kuchel,
Jennifer Schrack,
Martha Clare Morris,
David Weir,
Andrea A. Baccarelli,
Joanne M. Murabito,
Yoav BenShlomo,
Mark A. Espeland,
James L. Kirkland,
David Melzer,
Luigi Ferrucci
Publication year - 2019
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glz230
Subject(s) - epidemiology , life span , psychological intervention , gerontology , intervention (counseling) , medicine , disease , psychology , pathology , psychiatry
Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow.