Open AccessSystemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults
Author(s) -
Cutter A. Lindbergh,
Kaitlin B. Casaletto,
Adam M. Staffaroni,
Fanny M. Elahi,
Samantha Walters,
Michelle You,
John Neuhaus,
Will Rivera Contreras,
Paul Wang,
Anna Karydas,
Jesse A. Brown,
Amy Wolf,
Howie Rosen,
Yann Cobigo,
Joel H. Kramer
Publication year - 2019
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glz209
Subject(s) - white matter , atrophy , medicine , brain size , tumor necrosis factor alpha , hyperintensity , psychology , inflammation , systemic inflammation , cognition , magnetic resonance imaging , longitudinal study , endocrinology , neuroscience , pathology , radiology
Central nervous system levels of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age-related neurodegenerative diseases. The longitudinal relation between peripheral levels of TNF-α and typical brain aging is understudied. We hypothesized that within-person increases in systemic TNF-α would track with poorer brain health outcomes in functionally normal adults.