Open AccessEnergetic Cost of Walking and Brain Atrophy in Mid-to-Late Life
Author(s) -
Ryan J. Dougherty,
Fangyu Liu,
Yang An,
Amal A. Wanigatunga,
Qu Tian,
Christos Davatzikos,
Eleanor M. Simonsick,
Luigi Ferrucci,
Susan M. Resnick,
Jennifer Schrack
Publication year - 2021
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glab309
Subject(s) - brain size , gait , magnetic resonance imaging , physical medicine and rehabilitation , atrophy , preferred walking speed , white matter , neuroimaging , medicine , cardiology , psychology , neuroscience , radiology
Higher energetic costs for mobility are associated with declining gait speed, and slow gait is linked to cognitive decline and Alzheimer's disease. However, the physiological underpinnings of gait and brain health have not been well explored. We examined the associations of the energetic cost of walking with brain volume in cognitively unimpaired adults from the Baltimore Longitudinal Study of Aging.