Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses’ Health Study | Zendy

Philippine Fassier | Zendy; Jae H. Kang | Zendy; IMin Lee | Zendy; Francine Grodstein | Zendy; MarieNoël Vercambre | Zendy

Open Access

Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses’ Health Study

Author(s) -

Philippine Fassier,

Jae H. Kang,

IMin Lee,

Francine Grodstein,

MarieNoël Vercambre

Publication year - 2021

Publication title -

the journals of gerontology series a

Language(s) - English

Resource type - Journals

eISSN - 1758-535X

pISSN - 1079-5006

DOI - 10.1093/gerona/glab169

Subject(s) - apolipoprotein e , cognition , allele , gerontology , physical activity , apolipoprotein b , psychology , association (psychology) , cognitive decline , risk factor , medicine , clinical psychology , genetics , neuroscience , biology , dementia , physical medicine and rehabilitation , gene , cholesterol , psychotherapist , disease

The apolipoprotein E (APOE) e4 allele is a well-established genetic risk factor of brain aging. Vigorous physical activity may be particularly important in APOE-e4 carriers, but data have been inconsistent, likely due to differences in the timing of the physical activity assessment, definition of cognitive decline, and/or sample size.

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