Open AccessVigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses’ Health Study
Author(s) -
Philippine Fassier,
Jae H. Kang,
I-Min Lee,
Francine Grodstein,
Marie-Noël Vercambre
Publication year - 2021
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glab169
Subject(s) - cognition , odds ratio , metabolic equivalent , demography , cognitive decline , multinomial logistic regression , verbal fluency test , gerontology , medicine , apolipoprotein e , risk factor , prospective cohort study , logistic regression , effects of sleep deprivation on cognitive performance , psychology , physical activity , physical therapy , neuropsychology , dementia , psychiatry , disease , machine learning , sociology , computer science
The apolipoprotein E (APOE) e4 allele is a well-established genetic risk factor of brain aging. Vigorous physical activity may be particularly important in APOE-e4 carriers, but data have been inconsistent, likely due to differences in the timing of the physical activity assessment, definition of cognitive decline, and/or sample size.