Open AccessLaminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle
Author(s) -
Koyal Garg,
Ziad Mahmassani,
Svyatoslav Dvoretskiy,
M. Carmen Valero,
Heather D. Huntsman,
Samuel Lapp,
Yu-Fu Wu,
M S Stephen D Hauschka,
Dean J. Burkin,
Marni D. Boppart
Publication year - 2020
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glaa308
Subject(s) - anabolism , skeletal muscle , sarcopenia , medicine , endocrinology , plantaris muscle , stimulus (psychology) , chemistry , myocyte , biology , soleus muscle , psychology , psychotherapist
Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.