Open AccessA Metabolite Composite Score Attenuated a Substantial Portion of the Higher Mortality Risk Associated With Frailty Among Community-Dwelling Older Adults
Author(s) -
Megan M Marron,
Tamara B. Harris,
Robert M. Boudreau,
Clary B. Clish,
Steven C. Moore,
Rachel A. Murphy,
Venkatesh L. Murthy,
Jason L. Sanders,
Ravi Shah,
George C. Tseng,
Stacy G. Wendell,
Joseph M. Zmuda,
Anne B. Newman
Publication year - 2020
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glaa112
Subject(s) - metabolite , medicine , demography , epidemiology , proportional hazards model , gerontology , sociology
Frailty is more prevalent among black versus white older Americans. We previously identified 37 metabolites associated with the vigor to frailty spectrum using the Scale of Aging Vigor in Epidemiology (SAVE) among older black men from the Health, Aging, and Body Composition (Health ABC) study. Here, we sought to develop a metabolite composite score based on the 37 SAVE-associated metabolites and determine whether the composite score predicts mortality and whether it attenuates the association between frailty and mortality among older black men.