Open AccessGENE-ENZYME RELATIONS OF TRYPTOPHAN MUTANTS IN STREPTOMYCES COELICOLOR A3(2)
Author(s) -
Charles M. Smithers,
Paulinus P. Engel
Publication year - 1974
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/78.3.799
Subject(s) - tryptophan synthase , streptomyces coelicolor , biology , mutant , tryptophan , genetics , enzyme , gene , microbiology and biotechnology , phosphoribosyltransferase , isomerase , biochemistry , hypoxanthine guanine phosphoribosyltransferase , amino acid
Mutations in twenty-eight tryptophan mutants of S. coelicolor A3(2) were mapped relative to the nearest flanking markers. Mutants lacking single enzymatic activities for phosphoribosyltransferase, phosphoribosylanthranilate isomerase, indodeglycerol phosphate synthase, tryptophan synthase A and tryptophan synthase B were identified.